GAD1 gene polymorphisms are associated with hyperactivity in Attention-Deficit/Hyperactivity Disorder.

doi:10.1002/ajmg.b.32489

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Article

GAD1 gene polymorphisms are associated with hyperactivity in Attention-Deficit/Hyperactivity Disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2016

Bruxel Estela M, Akutagava-Martins Glaucia C, Salatino-Oliveira Angélica, Genro Julia P, Zeni Cristian P, Polanczyk Guilherme V, Chazan Rodrigo, Schmitz Marcelo, Rohde Luis A, Hutz Mara H

Abstract excerpt

Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood. Recent studies suggest a role for γ-aminobutyric acid (GABA) on ADHD hyperactive/impulsive symptoms due to behavioral disinhibition resulting from inappropriate modulation of both glutamatergic and GABAergic signaling. The glutamic acid decarboxylase (GAD1) gene encodes a key enzyme of GABA...

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PMID: 27530595
DOI: 10.1002/ajmg.b.32489

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GAD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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