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Article

Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity.

PloS one - 1 Jan 2012

Ishisaka Mitsue, Kakefuda Kenichi, Oyagi Atsushi, Ono Yoko, Tsuruma Kazuhiro, Shimazawa Masamitsu, Kitaichi Kiyoyuki, Hara Hideaki

Abstract excerpt

BACKGROUND: Diacylglycerol kinase (DGK) is an enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. DGKβ is one of the subtypes of the DGK family and regulates many intracellular signaling pathways in the central nervous system. Previously, we demonstrated that DGKβ knockout (KO) mice showed various dysfunctions of higher brain function, such as cognitive impairment (with lower spine density),...

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Identifiers

PMID: 22590645
DOI: 10.1371/journal.pone.0037058
PMCID: PMC3349656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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