Article
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice.
Molecular and cellular neurosciences - 1 Jun 2001
Prosser H M, Gill C H, Hirst W D, Grau E, Robbins M, Calver A, Soffin E M, Farmer C E, Lanneau C, Gray J, Schenck E, Warmerdam B S, Clapham C, Reavill C, Rogers D C, Stean T, Upton N, Humphreys K, Randall A, Geppert M, Davies C H, Pangalos M N
Abstract excerpt
The recent cloning of two GABA(B) receptor subunits, GABA(B1) and GABA(B2), has raised the possibility that differences in GABA(B) receptor subunit composition may give rise to pharmacologically or functionally distinct receptors. If present, such molecular diversity could permit the selective targeting of GABA(B) receptor subtypes specifically involved in pathologies such as drug addiction, spasticity, pain, and...
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