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Article

Glyoxalase 1 Inhibitor Alleviates Autism-like Phenotype in a Prenatal Valproic Acid-Induced Mouse Model.

ACS chemical neuroscience - 18 Nov 2020

Wang Kui, Li Na, Xu Min, Huang Meng, Huang Fei

Abstract excerpt

Autism spectrum disorder (ASD) is a severe neurological and developmental disorder that impairs a person's ability to socialize and communicate and affects behavior. The number of patients diagnosed with ASD has risen rapidly. However, the pathophysiology of ASD is poorly understood, and drugs for ASD treatment are strikingly limited. This study aims to evaluate the roles of glyoxalase 1 (GLO1)-methylglyoxal...

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PMID: 33166134
DOI: 10.1021/acschemneuro.0c00482

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