Article
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice.
Nature medicine - 1 May 2011
Won Hyejung, Mah Won, Kim Eunjin, Kim Jae-Won, Hahm Eun-Kyoung, Kim Myoung-Hwan, Cho Sukhee, Kim Jeongjin, Jang Hyeran, Cho Soo-Churl, Kim Boong-Nyun, Shin Min-Sup, Seo Jinsoo, Jeong Jaeseung, Choi Se-Young, Kim Daesoo, Kang Changwon, Kim Eunjoon
Abstract excerpt
Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder that affects ~5% of school-aged children; however, the mechanisms underlying ADHD remain largely unclear. Here we report a previously unidentified association between G protein-coupled receptor kinase-interacting protein-1 (GIT1) and ADHD in humans. An intronic single-nucleotide polymorphism in GIT1, the minor allele of which causes reduced...
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