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Article

p27Kip1 and p21Cip1 collaborate in the regulation of transcription by recruiting cyclin-Cdk complexes on the promoters of target genes.

Nucleic acids research - 18 Aug 2015

Orlando Serena, Gallastegui Edurne, Besson Arnaud, Abril Gabriel, Aligué Rosa, Pujol Maria Jesus, Bachs Oriol

Abstract excerpt

Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication. During the G1 phase of the cell cycle, sequential phosphorylation of p130 by cyclin-dependent kinases (Cdks) disrupts these complexes allowing gene expression. The Cdk inhibitor and tumor suppressor p27(Kip1) associates with p130 and E2F4 by its carboxyl domain on the promoters of target...

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Identifiers

PMID: 26071952
DOI: 10.1093/nar/gkv593
PMCID: PMC4538812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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