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Article

Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice.

Laboratory investigation; a journal of technical methods and pathology - 1 Nov 2011

García-Fernández Rosa A, García-Palencia Pilar, Sánchez María Á, Gil-Gómez Gabriel, Sánchez Belén, Rollán Eduardo, Martín-Caballero Juan, Flores Juana M

Abstract excerpt

The cell cycle inhibitors p21(Waf1/Cip1) and p27(Kip1) are frequently downregulated in many human cancers, and correlate with a worse prognosis. We show here that combined deficiency in p21 and p27 proteins in mice is linked to more aggressive spontaneous tumorigenesis, resulting in a decreased lifespan. The most common tumors developed in p21p27 double-null mice were endocrine, with a higher incidence of...

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PMID: 21876534
DOI: 10.1038/labinvest.2011.133

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Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice.PMID 21876534Read ↗

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