Article
Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes.
Oncotarget - 22 Sept 2015
Cochran Rory L, Cidado Justin, Kim Minsoo, Zabransky Daniel J, Croessmann Sarah, Chu David, Wong Hong Yuen, Beaver Julia A, Cravero Karen, Erlanger Bracha, Parsons Heather, Heaphy Christopher M, Meeker Alan K, Lauring Josh, Park Ben Ho
Abstract excerpt
Clinical genetic testing of BRCA1 and BRCA2 is commonly performed to identify specific individuals at risk for breast and ovarian cancers who may benefit from prophylactic therapeutic interventions. Unfortunately, it is evident that deleterious BRCA1 alleles demonstrate variable penetrance and that many BRCA1 variants of unknown significance (VUS) exist. In order to further refine hereditary risks that may be...
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