Article
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2011
Konishi Hiroyuki, Mohseni Morassa, Tamaki Akina, Garay Joseph P, Croessmann Sarah, Karnan Sivasundaram, Ota Akinobu, Wong Hong Yuen, Konishi Yuko, Karakas Bedri, Tahir Khola, Abukhdeir Abde M, Gustin John P, Cidado Justin, Wang Grace M, Cosgrove David, Cochran Rory, Jelovac Danijela, Higgins Michaela J, Arena Sabrina, Hawkins Lauren, Lauring Josh, Gross Amy L, Heaphy Christopher M, Hosokawa Yositaka, Gabrielson Edward, Meeker Alan K, Visvanathan Kala, Argani Pedram, Bachman Kurtis E, Park Ben Ho
Abstract excerpt
Biallelic inactivation of cancer susceptibility gene BRCA1 leads to breast and ovarian carcinogenesis. Paradoxically, BRCA1 deficiency in mice results in early embryonic lethality, and similarly, lack of BRCA1 in human cells is thought to result in cellular lethality in view of BRCA1's essential function. To survive homozygous BRCA1 inactivation during tumorigenesis, precancerous cells must accumulate additional...
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