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Article

Gene expression profiling after radiation-induced DNA damage is strongly predictive of BRCA1 mutation carrier status.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2004

Kote-Jarai Zsofia, Williams Richard D, Cattini Nicola, Copeland Maria, Giddings Ian, Wooster Richard, tePoele Robert H, Workman Paul, Gusterson Barry, Peacock John, Gui Gerald, Campbell Colin, Eeles Ros

Abstract excerpt

PURPOSE: The impact of the presence of a germ-line BRCA1 mutation on gene expression in normal breast fibroblasts after radiation-induced DNA damage has been investigated. EXPERIMENTAL DESIGN: High-density cDNA microarray technology was used to identify differential responses to DNA damage in fib...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14871973
DOI: 10.1158/1078-0432.ccr-1067-3

Genes

BRCA1
ATR
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14871973-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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