Article
Evaluation of Mutational Testing of Preneoplastic Barrett's Mucosa by Next-Generation Sequencing of Formalin-Fixed, Paraffin-Embedded Endoscopic Samples for Detection of Concurrent Dysplasia and Adenocarcinoma in Barrett's Esophagus.
The Journal of molecular diagnostics : JMD - 1 Jul 2015
Del Portillo Armando, Lagana Stephen M, Yao Yuan, Uehara Takeshi, Jhala Nirag, Ganguly Tapan, Nagy Peter, Gutierrez Jorge, Luna Aesis, Abrams Julian, Liu Yang, Brand Randall, Sepulveda Jorge L, Falk Gary W, Sepulveda Antonia R
Abstract excerpt
Barrett's intestinal metaplasia (BIM) may harbor genomic mutations before the histologic appearance of dysplasia and cancer and requires frequent surveillance. We explored next-generation sequencing to detect mutations with the analytical sensitivity required to predict concurrent high-grade dysp...
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