Article
Single nucleotide polymorphisms of ADRB2 gene and their association with susceptibility for Plasmodium falciparum malaria and asthma in an Indian population.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2013
Saadi Abdul Vahab, Gupta Himanshu, Angural Arshia, Dhanya Sreeja Kumari, Mony Sridevi, Oberoi Devesh, D'Souza Sydney C, Sahoo Ramesh Chandra, Hande Manjunath H, Gopinath Puthiya Mundyat, Satyamoorthy Kapaettu
Abstract excerpt
The essential route to blood parasitaemia in malaria, erythrocyte invasion is facilitated by activation of the G-protein coupled receptor signaling pathway mediated by the β2-adrenoreceptor as one of the proteins on the surface of red blood cells. The effectiveness of bronchodilators and inhaled corticosteroids in the clinical treatment for asthma patients also depend on polymorphisms in the β2-adrenoreceptor...
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