Article
miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2015
Eedunuri Vijay Kumar, Rajapakshe Kimal, Fiskus Warren, Geng Chuandong, Chew Sue Anne, Foley Christopher, Shah Shrijal S, Shou John, Mohamed Junaith S, Coarfa Cristian, O'Malley Bert W, Mitsiades Nicholas
Abstract excerpt
The p160 family of steroid receptor coactivators (SRCs) are pleiotropic transcription factor coactivators and "master regulators" of gene expression that promote cancer cell proliferation, survival, metabolism, migration, invasion, and metastasis. Cancers with high p160 SRC expression exhibit poor clinical outcomes and resistance to therapy, highlighting the SRCs as critical oncogenic drivers and, thus,...
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