Article
Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells.
PloS one - 1 Jan 2014
Tamim Saleh, Vo Dat T, Uren Philip J, Qiao Mei, Bindewald Eckart, Kasprzak Wojciech K, Shapiro Bruce A, Nakaya Helder I, Burns Suzanne C, Araujo Patricia R, Nakano Ichiro, Radek Agnes J, Kuersten Scott, Smith Andrew D, Penalva Luiz O F
Abstract excerpt
miR-137 plays critical roles in the nervous system and tumor development; an increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma therapy, we conducted genome-wide target mappin...
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