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Article

SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.

PLoS genetics - 1 Mar 2017

Suresh Shruthy, Durakoglugil Deniz, Zhou Xiaorong, Zhu Bokai, Comerford Sarah A, Xing Chao, Xie Xian-Jin, York Brian, O'Donnell Kathryn A

Abstract excerpt

Hepatocellular carcinoma (HCC) is the fifth most common solid tumor in the world and the third leading cause of cancer-associated deaths. A Sleeping Beauty-mediated transposon mutagenesis screen previously identified mutations that cooperate with MYC to accelerate liver tumorigenesis. This revealed a tumor suppressor role for Steroid Receptor Coactivator 2/Nuclear Receptor Coactivator 2 (Src-2/Ncoa2) in liver...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28273073
DOI: 10.1371/journal.pgen.1006650
PMCID: PMC5362238

Genes

SRC
MYC
CADM4
DKK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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