Article

Linked-read whole-genome sequencing resolves common and private structural variants in multiple myeloma

2021-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Multiple myeloma (MM) is an incurable and aggressive plasma cell malignancy characterized by a complex karyotype with multiple structural variants (SVs) and copy number variations (CNVs). Linked-read whole-genome sequencing (lrWGS) allows for refined detection and reconstruction of SVs by providing long-range genetic information from standard short-read sequencing. This makes lrWGS an attractive...

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Literature Corpus work: c81a08ed-4cb1-5243-9afd-69219ffa380e
DOI: 10.1101/2021.12.09.471893

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