Unique molecular assay (UMA): a next-generation sequencing targeted panel for efficient and comprehensive genomic profiling and risk stratification of multiple myeloma.

doi:10.3324/haematol.2025.287559

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Article

Unique molecular assay (UMA): a next-generation sequencing targeted panel for efficient and comprehensive genomic profiling and risk stratification of multiple myeloma.

Haematologica - 1 Oct 2025

Poletti Andrea, Taurisano Barbara, Mazzocchetti Gaia, Lionetti Marta, Martello Marina, Vuong Viola Meixian, Solli Vincenza, Marzocchi Giulia, Maeda Akihiro, Vigliotta Ilaria, Borsi Enrica, Armuzzi Silvia, Pistis Ignazia, Marella Alessio, Fabris Sonia, Tacchetti Paola, Mancuso Katia, Rizzello Ilaria, Pantani Lucia, Testoni Nicoletta, Cavo Michele, Zamagni Elena, Bolli Niccolò, Terragna Carolina

Abstract excerpt

Multiple myeloma (MM) is characterized by genetic abnormalities in plasma cells, requiring precise genomic characterization for effective risk stratification and treatment. This study presents the Unique Molecular Assay (UMA) panel, a targeted DNA-sequencing approach designed to capture critical genomic aberrations in MM, including canonical immunoglobulin heavy chain translocations (t-IgH), copy number...

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Topics

Humans
Multiple Myeloma
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genomics

Male

Mutation

Female

DNA Copy Number Variations

Risk Assessment

Aged

Middle Aged

In Situ Hybridization, Fluorescence

Reproducibility of Results

Aged, 80 and over

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 40371906
DOI: 10.3324/haematol.2025.287559
PMCID: PMC12485320

Genes

TP53

Provenance

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