R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability.

doi:10.1200/JCO.2014.59.3590

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Article

R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jul 2015

Chen Hsuan-Yu, Yu Sung-Liang, Ho Bing-Ching, Su Kang-Yi, Hsu Yi-Chiung, Chang Chi-Sheng, Li Yu-Cheng, Yang Shi-Yi, Hsu Pin-Yen, Ho Hao, Chang Ya-Hsuan, Chen Chih-Yi, Yang Hwai-I, Hsu Chung-Ping, Yang Tsung-Ying, Chen Kun-Chieh, Hsu Kuo-Hsuan, Tseng Jeng-Sen, Hsia Jiun-Yi, Chuang Cheng-Yen, Yuan Shinsheng, Lee Mei-Hsuan, Liu Chia-Hsin, Wu Guan-I, Hsiung Chao A, Chen Yuh-Min, Wang Chih-Liang, Huang Ming-Shyan, Yu Chong-Jen, Chen Kuan-Yu, Tsai Ying-Huang, Su Wu-Chou, Chen Huei-Wen, Chen Jeremy J W, Chen Chien-Jen, Chang Gee-Chen, Yang Pan-Chyr, Li Ker-Chau

Abstract excerpt

PURPOSE: Adenocarcinoma is the most dominant type of lung cancer in never-smoker patients. The risk alleles from genome-wide association studies have small odds ratios and unclear biologic roles. Here we have taken an approach featuring suitable medical actionability to identify alleles with low population frequency but high disease-causing potential. PATIENTS AND METHODS: Whole-genome sequencing was performed...

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PMID: 26056182
DOI: 10.1200/JCO.2014.59.3590

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YAP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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