Article
Systematic cell-type resolved transcriptomes of 8 tissues in 8 lab and wild-derived mouse strains capture global and local expression variation.
Cell genomics - 8 Apr 2026
Rebboah Elisabeth, Weber Ryan, Abdollahzadeh Elnaz, Swarna Nikhila, Sullivan Delaney K, Trout Diane, Reese Fairlie, Liang Heidi Yahan, Filimban Ghassan, Mahdipoor Parvin, Duffield Margaret, Mojaverzargar Romina, Taghizadeh Erisa, Fattahi Negar, Mojgani Negar, Zhang Haoran, Loving Rebekah K, Carilli Maria, Booeshaghi A Sina, Kawauchi Shimako, Hallgrímsdóttir Ingileif B, Williams Brian A, MacGregor Grant R, Pachter Lior, Wold Barbara J, Mortazavi Ali
Abstract excerpt
Mapping the impact of genomic variation on gene expression provides insight into the molecular basis of complex phenotypic traits and disease predisposition. Mouse models offer a controlled framework to capture genomic diversity across tissues. As part of the IGVF consortium, we profiled the transcriptomes of eight tissues from each founder strain of the Collaborative Cross using single-nucleus RNA sequencing....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.