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Article

Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer.

The Journal of biological chemistry - 27 Feb 2009

Tvorogov Denis, Sundvall Maria, Kurppa Kari, Hollmén Maija, Repo Susanna, Johnson Mark S, Elenius Klaus

Abstract excerpt

Cancer drugs targeting ErbB receptors, such as epidermal growth factor receptor and ErbB2, are currently in clinical use. However, the role of ErbB4 as a potential cancer drug target has remained controversial. Recently, somatic mutations altering the coding region of ErbB4 were described in patients with breast, gastric, colorectal, or non-small cell lung cancer, but the functional significance of these...

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PMID: 19098003
DOI: 10.1074/jbc.M805438200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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