Article
Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.
PloS one - 9 May 2007
Marks Jenifer L, McLellan Michael D, Zakowski Maureen F, Lash Alex E, Kasai Yumi, Broderick Stephen, Sarkaria Inderpal S, Pham Duykhanh, Singh Bhuvanesh, Miner Tracie L, Fewell Ginger A, Fulton Lucinda L, Mardis Elaine R, Wilson Richard K, Kris Mark G, Rusch Valerie W, Varmus Harold, Pao William
Abstract excerpt
BACKGROUND: Fifty percent of lung adenocarcinomas harbor somatic mutations in six genes that encode proteins in the EGFR signaling pathway, i.e., EGFR, HER2/ERBB2, HER4/ERBB4, PIK3CA, BRAF, and KRAS. We performed mutational profiling of a large cohort of lung adenocarcinomas to uncover other potential somatic mutations in genes of this signaling pathway that could contribute to lung tumorigenesis....
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