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Article

A constitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities.

Oncogene - 18 Jan 2007

Vidal G A, Clark D E, Marrero L, Jones F E

Abstract excerpt

In the normal breast, ERBB4 regulates epithelial differentiation and functions as a nuclear chaperone for signal transducer and activator of transcription (STAT) 5A, thereby stimulating milk-gene expression. In addition, ERBB4 functions as a proapoptotic protein, suppressing the growth of malignant cells. We hypothesize that these ERBB4 activities can be marshaled to suppress the growth of breast tumors. To this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16832345
DOI: 10.1038/sj.onc.1209794

Genes

ERBB4
ERBB2
STAT5A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A constitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities.PMID 16832345Read ↗

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