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Article

Mutational landscape and characteristics of ERBB2 in non-small cell lung cancer.

Thoracic cancer - 1 Jun 2020

Wei Xue-Wu, Gao Xin, Zhang Xu-Chao, Yang Jin-Ji, Chen Zhi-Hong, Wu Yi-Long, Zhou Qing

Abstract excerpt

BACKGROUND: Tyrosine kinase domain (TKD) mutation and particularly exon 20 insertion mutations of ERBB2 have been extensively reported in non-small cell lung cancer (NSCLC). Due to the increased accessibility of next-generation sequencing, more ERBB2 mutations within the non-TKD can be detected in clinical practice. Nevertheless, the clinical significance of non-TKD mutations remains unknown. Hence, this study...

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Identifiers

PMID: 32291971
DOI: 10.1111/1759-7714.13419
PMCID: PMC7262945

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