Article
An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations.
Cancer research communications - 1 Jan 2022
Chakroborty Deepankar, Ojala Veera K, Knittle Anna M, Drexler Jasmin, Tamirat Mahlet Z, Ruzicka Regina, Bosch Karin, Woertl Johanna, Schmittner Susanne, Elo Laura L, Johnson Mark S, Kurppa Kari J, Solca Flavio, Elenius Klaus
Abstract excerpt
Despite the relatively high frequency of somatic ERBB4 mutations in various cancer types, only a few activating ERBB4 mutations have been characterized, primarily due to lack of mutational hotspots in the ERBB4 gene. Here, we utilized our previously published pipeline, an in vitro screen for activating mutations, to perform an unbiased functional screen to identify potential activating ERBB4 mutations from a...
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