Article
Transcription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2015
Pinacho Raquel, Saia Gregory, Meana J Javier, Gill Grace, Ramos Belén
Abstract excerpt
Transcription factors play important roles in the control of neuronal function in physiological and pathological conditions. We previously reported reduced levels of transcription factor SP4 protein, but not transcript, in the cerebellum in bipolar disorder and associated with more severe negative symptoms in schizophrenia. We have recently reported phosphorylation of Sp4 at S770, which is regulated by membrane...
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