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Article

Over-representation of potential SP4 target genes within schizophrenia-risk genes.

Molecular psychiatry - 1 Feb 2022

Zhou Xianjin

Abstract excerpt

Reduction of Sp4 expression causes age-dependent hippocampal vacuolization and many other intermediate phenotypes of schizophrenia in Sp4 hypomorphic mice. Recent human genetic studies from both the Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) and the Genome-Wide Association Study (GWAS) validated SP4 as a schizophrenia-risk gene over the exome-wide or the genome-wide significance. Truncation of the...

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Identifiers

PMID: 34750502
DOI: 10.1038/s41380-021-01376-8
PMCID: PMC9054665

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