Article

Over-Representation of Potential SP4 Target Genes within Schizophrenia-Risk Genes

2021-07-15

Abstract excerpt

Reduction of Sp4 expression causes age-dependent hippocampal vacuolization and many other intermediate phenotypes of schizophrenia in Sp4 hypomorphic mice. Recent human genetic studies from both the Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) and the Genome-Wide Association Study (GWAS) validated SP4 as a schizophrenia-risk gene over the exome-wide or the genome-wide significance. Truncation of human SP4...

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Literature Corpus work: f4b9949e-0693-57cc-971d-66c0d6d1e49f
DOI: 10.1101/2021.07.14.452377

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