Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of Drosophila uncoupling protein 5 in metabolism and aging.

Genetics - 1 Mar 2006

Sánchez-Blanco Adolfo, Fridell Yih-Woei C, Helfand Stephen L

Abstract excerpt

A novel uncoupling protein, UCP5, has recently been characterized as a functional mitochondrial uncoupler in Drosophila. Here we demonstrate that UCP5 knockout (UCP5KO) flies are highly sensitive to starvation stress, a phenotype that can be reversed by ectopic neuronal expression of UCP5. UCP5KO flies live longer than controls on low-calorie diets, have a decreased level of fertility, and gain less weight than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Animals, Genetically Modified
Share to Homeostasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infertility, Female

Share to Mitochondrial Proteins

Share to Starvation

Share to Triglycerides

Share to Weight Gain

Source

Open in PubMed Open full text

Identifiers

PMID: 16387864
DOI: 10.1534/genetics.105.053389
PMCID: PMC1456275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of Drosophila uncoupling protein 5 in metabolism and aging.PMID 16387864Read ↗

The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing.Semantic proximity Read ↗

Developmental Programming by High Fructose Decreases Phosphorylation Efficiency in Aging Offspring Brain Mitochondria, Correlating with Enhanced UCP5 ExpressionSemantic proximity Read ↗

Circadian regulation of mitochondrial uncoupling and lifespan.Semantic proximity Read ↗

Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation.Semantic proximity Read ↗

Drosophila as a Genetic Model System to Study Organismal Energy MetabolismSemantic proximity Read ↗

Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity.Semantic proximity Read ↗

Identification of Flavin-Containing Monooxygenase 5 (FMO5) as a Regulator of Glucose Homeostasis and a Potential Sensor of Gut Bacteria.Semantic proximity Read ↗

Deficiency of <i>Irx5</i> protects mice from diet-induced obesity and associated metabolic abnormalitiesSemantic proximity Read ↗

dFatp regulates nutrient distribution and long-term physiology in Drosophila.Semantic proximity Read ↗

Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies.Semantic proximity Read ↗

Loss of neurofibromin alters adult metabolism via effects during a developmental critical periodSemantic proximity Read ↗

Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.