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Targeted discovery of polyketides with antioxidant activity through integrated omics and cocultivation strategies

1 Nov 2024

Abstract excerpt

ABSTRACT Fungi generate a diverse array of bioactive compounds with significant pharmaceutical applications. However, the chemical diversity of natural products in fungi remains largely unexplored. Here, we present a paradigm for specifically discovering diverse and bioactive compounds from fungi by integrating genome mining with building block molecular network and coculture analysis. Through pangenome and...

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PMID: 39445804
DOI: 10.1128/aem.01603-24

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