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Article

A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation.

Nucleic acids research - 15 Dec 2003

Ono Yuuki, Tomita Kazunori, Matsuura Akira, Nakagawa Takuro, Masukata Hisao, Uritani Masahiro, Ushimaru Takashi, Ueno Masaru

Abstract excerpt

Replication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein involved in DNA replication, recombination and repair. In Saccharomyces cerevisiae, several mutants in the RFA1 gene encoding the large subunit of RPA have been isolated and one of the mutants with a missense allele, rfa1-D228Y, shows a synergistic reduction in telomere length when combined with a yku70 mutation. So far, only one...

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PMID: 14654689
DOI: 10.1093/nar/gkg917
PMCID: PMC291861

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation.PMID 14654689Read ↗

Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance.Semantic proximity Read ↗

The Schizosaccharomyces pombe rad11+ gene encodes the large subunit of replication protein A.Semantic proximity Read ↗

Replication protein A is required for meiotic recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

A novel allele of Saccharomyces cerevisiae RFA1 that is deficient in recombination and repair and suppressible by RAD52.Semantic proximity Read ↗

A mutation in the gene encoding the Saccharomyces cerevisiae single-stranded DNA-binding protein Rfa1 stimulates a RAD52-independent pathway for direct-repeat recombination.Semantic proximity Read ↗

Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA.Semantic proximity Read ↗

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.Semantic proximity Read ↗

Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitro.Semantic proximity Read ↗

An allele of RFA1 suppresses RAD52-dependent double-strand break repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein rfa1 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification and characterization of the rlp1+, the novel Rad51 paralog in the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair.Semantic proximity Read ↗

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