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Article

Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3.

American journal of physiology. Renal physiology - 15 Aug 2015

Krishnan Devishree, Liu Lei, Wiebe Shane A, Casey Joseph R, Cordat Emmanuelle, Alexander R Todd

Abstract excerpt

Two-thirds of sodium filtered by the renal glomerulus is reabsorbed from the proximal tubule via a sodium/proton exchanger isoform 3 (NHE3)-dependent mechanism. Since sodium and bicarbonate reabsorption are coupled, we postulated that the molecules involved in their reabsorption [NHE3 and carbonic anhydrase II (CAII)] might physically and functionally interact. Consistent with this, CAII and NHE3 were closely...

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Identifiers

PMID: 26041446
DOI: 10.1152/ajprenal.00464.2014
PMCID: PMC4959884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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