Article
Nickel and extracellular acidification inhibit the water permeability of human aquaporin-3 in lung epithelial cells.
The Journal of biological chemistry - 8 Aug 2003
Zelenina Marina, Bondar Alexander A, Zelenin Sergey, Aperia Anita
Abstract excerpt
Nickel is a common cause of pneumoconiosis. Here, we show that nickel inactivates aquaporin (AQP)-3, the water channel expressed apically in epithelial cells of human terminal airways. Human AQP3 was transiently transfected into human lung cells, and water permeability was measured in transfected and neighboring untransfected cells. Incubation with NiCl2 rapidly, dose-dependently, and reversibly decreased water...
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