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Article

Regulation of intestinal Cl-/HCO3- exchanger SLC26A3 by intracellular pH.

American journal of physiology. Cell physiology - 1 Jun 2009

Hayashi Hisayoshi, Suruga Kazuhito, Yamashita Yukari

Abstract excerpt

SLC26A3, a Cl(-)/HCO(3)(-) exchanger, is highly expressed in intestinal epithelial cells, and its mutations cause congenital chloride diarrhea. This suggests that SLC26A3 plays a key role in NaCl absorption in the intestine. Electroneutral NaCl absorption in the intestine is mediated by functional coupling of the Na(+)/H(+) exchanger and Cl(-)/HCO(3)(-) exchanger. It is proposed that the coupling of these...

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Identifiers

PMID: 19321737
DOI: 10.1152/ajpcell.00638.2008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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