Article
Mutation burden of rare variants in schizophrenia candidate genes.
PloS one - 1 Jan 2015
Girard Simon L, Dion Patrick A, Bourassa Cynthia V, Geoffroy Steve, Lachance-Touchette Pamela, Barhdadi Amina, Langlois Mathieu, Joober Ridha, Krebs Marie-Odile, Dubé Marie-Pierre, Rouleau Guy A
Abstract excerpt
BACKGROUND: Schizophrenia (SCZ) is a very heterogeneous disease that affects approximately 1% of the general population. Recently, the genetic complexity thought to underlie this condition was further supported by three independent studies that identified an increased number of damaging de novo mutations DNM in different SCZ probands. While these three reports support the implication of DNM in the pathogenesis of...
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