Article
Identification of de novo mutations in prenatal neurodevelopment-associated genes in schizophrenia in two Han Chinese patient-sibling family-based cohorts.
Translational psychiatry - 1 Sept 2020
Jiang Shan, Zhou Daizhan, Wang Yin-Ying, Jia Peilin, Wan Chunling, Li Xingwang, He Guang, Cao Dongmei, Jiang Xiaoqian, Kendler Kenneth S, Tsuang Ming, Mize Travis, Wu Jain-Shing, Lu Yimei, He Lin, Chen Jingchun, Zhao Zhongming, Chen Xiangning
Abstract excerpt
Schizophrenia (SCZ) is a severe psychiatric disorder with a strong genetic component. High heritability of SCZ suggests a major role for transmitted genetic variants. Furthermore, SCZ is also associated with a marked reduction in fecundity, leading to the hypothesis that alleles with large effects on risk might often occur de novo. In this study, we conducted whole-genome sequencing for 23 families from two...
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