Back to search

Article

Identification of<i>de novo</i>mutations in prenatal neurodevelopment-associated genes in schizophrenia in two Han Chinese patient-sibling family-based cohorts

2019-11-04

Abstract excerpt

Schizophrenia (SCZ) is a severe psychiatric disorder with a strong genetic component. High heritability of SCZ suggests a major role for transmitted genetic variants. Furthermore, SCZ is also associated with a marked reduction in fecundity, leading to the hypothesis that alleles with large effects on risk might often occur de novo. In this study, we conducted whole-genome sequencing for 23 families from two cohort...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4f881dd0-15f6-5c97-a808-2f340b1e2483
DOI
10.1101/19011007
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of<i>de novo</i>mutations in prenatal neurodevelopment-associated genes in schizophrenia in two Han Chinese patient-sibling family-based cohortsDOI 10.1101/19011007
Identification of de novo mutations in prenatal neurodevelopment-associated genes in schizophrenia in two Han Chinese patient-sibling family-based cohorts.Semantic proximity
Exome sequencing in schizophrenia-affected parent-offspring trios reveals risk conferred by protein-coding de novo mutations.Semantic proximity
Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients.Semantic proximity
De novo mutations disturb early brain development more frequently than common variants in schizophrenia.Semantic proximity
Mutation burden of rare variants in schizophrenia candidate genes.Semantic proximity
De novo genic mutations among a Chinese autism spectrum disorder cohort.Semantic proximity
Investigation of rare variants in LRP1, KPNA1, ALS2CL and ZNF480 genes in schizophrenia patients reflects genetic heterogeneity of the disease.Semantic proximity
Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia.Semantic proximity
Genetic studies of schizophrenia: an update.Semantic proximity
Mutations of schizophrenia risk gene <i>SETD1A</i> dysregulate synaptic function in human neuronsSemantic proximity
Oligogenic rare variant contributions in schizophrenia and their convergence with genes harbouring <i>de novo</i> mutations in schizophrenia, autism and intellectual disability: Evidence from multiplex familiesSemantic proximity
Rare nonsynonymous germline and mosaic de novo variants in Japanese patients with schizophrenia.Semantic proximity
Select a neighboring publication to make it the new centre.