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Article

Association Between Specific Mutations in KRAS Codon 12 and Colorectal Liver Metastasis.

JAMA surgery - 1 Aug 2015

Margonis Georgios Antonios, Kim Yuhree, Spolverato Gaya, Ejaz Aslam, Gupta Rohan, Cosgrove David, Anders Robert, Karagkounis Georgios, Choti Michael A, Pawlik Timothy M

Abstract excerpt

IMPORTANCE: Currently, one of the most commonly available biomarkers in the treatment of patients with colorectal liver metastases (CRLM) is the Kirsten rat sarcoma viral oncogene homolog (KRAS); however, the prognostic implications of specific mutations of the KRAS gene are still not well defined. OBJECTIVE: To investigate the prognostic impact of specific KRAS mutations on patients undergoing liver resection...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26038887
DOI: 10.1001/jamasurg.2015.0313
PMCID: PMC4696064

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association Between Specific Mutations in KRAS Codon 12 and Colorectal Liver Metastasis.PMID 26038887Read ↗

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Specific mutations in KRAS codon 12 are associated with worse overall survival in patients with advanced and recurrent colorectal cancer.Semantic proximity Read ↗

Effect of KRAS Mutation on Long-Term Outcomes of Patients Undergoing Hepatic Resection for Colorectal Liver Metastases.Semantic proximity Read ↗

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