Article
KRAS exon 2 codon 13 mutation is associated with a better prognosis than codon 12 mutation following lung metastasectomy in colorectal cancer.
Oncotarget - 10 Jan 2017
Renaud Stéphane, Guerrera Francesco, Seitlinger Joseph, Costardi Lorena, Schaeffer Mickaël, Romain Benoit, Mossetti Claudio, Claire-Voegeli Anne, Filosso Pier Luigi, Legrain Michèle, Ruffini Enrico, Falcoz Pierre-Emmanuel, Oliaro Alberto, Massard Gilbert
Abstract excerpt
INTRODUCTION: The utilization of molecular markers as routinely used biomarkers is steadily increasing. We aimed to evaluate the potential different prognostic values of KRAS exon 2 codons 12 and 13 after lung metastasectomy in colorectal cancer (CRC). RESULTS: KRAS codon 12 mutations were observed in 116 patients (77%), whereas codon 13 mutations were observed in 34 patients (23%). KRAS codon 13 mutations were...
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