Article
The CXCR3(+)CD56Bright phenotype characterizes a distinct NK cell subset with anti-fibrotic potential that shows dys-regulated activity in hepatitis C.
PloS one - 1 Jan 2012
Eisenhardt Marianne, Glässner Andreas, Krämer Benjamin, Körner Christian, Sibbing Bernhard, Kokordelis Pavlos, Nischalke Hans Dieter, Sauerbruch Tilman, Spengler Ulrich, Nattermann Jacob
Abstract excerpt
BACKGROUND: In mouse models, natural killer (NK) cells have been shown to exert anti-fibrotic activity via killing of activated hepatic stellate cells (HSC). Chemokines and chemokine receptors critically modulate hepatic recruitment of NK cells. In hepatitis C, the chemokine receptor CXCR3 and its ligands have been shown to be associated with stage of fibrosis suggesting a role of these chemokines in HCV...
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