Article
Mutation of N-linked glycosylation at Asn548 in CD133 decreases its ability to promote hepatoma cell growth.
Oncotarget - 21 Aug 2015
Liu Ying, Ren Shifang, Xie Liqi, Cui Chunhong, Xing Yang, Liu Chanjuan, Cao Benjin, Yang Fan, Li Yinan, Chen Xiaoning, Wei Yuanyan, Lu Haojie, Jiang Jianhai
Abstract excerpt
The membrane glycoprotein CD133 is a popular marker for cancer stem cells and contributes to cancer initiation and invasion in a number of tumor types. CD133 promotes tumorigenesis partly through an interaction between its phosphorylated Y828 residue and the PI3K regulatory subunit p85, and the interaction with β-catenin. Although CD133 glycosylation is supposed to be associated with its function, the...
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