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The Impact of Glycosylation on the Functional Activity of CD133 and the Accuracy of Its Immunodetection

18 Jun 2024

Abstract excerpt

The membrane glycoprotein CD133 (prominin-1) is widely regarded as the main molecular marker of cancer stem cells, which are the most malignant cell subpopulation within the tumor, responsible for tumor growth and metastasis. For this reason, CD133 is considered a promising prognostic biomarker and molecular target for antitumor therapy. Under normal conditions, CD133 is present on the cell membrane in...

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PMID: 38927329
DOI: 10.3390/biology13060449

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