Article
Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2020
Park Diane Dayoung, Phoomak Chatchai, Xu Gege, Olney Laura P, Tran Khiem A, Park Simon S, Haigh Nathan E, Luxardi Guillaume, Lert-Itthiporn Worachart, Shimoda Michiko, Li Qiongyu, Matoba Nobuyuki, Fierro Fernando, Wongkham Sopit, Maverakis Emanual, Lebrilla Carlito B
Abstract excerpt
Membrane-bound oligosaccharides form the interfacial boundary between the cell and its environment, mediating processes such as adhesion and signaling. These structures can undergo dynamic changes in composition and expression based on cell type, external stimuli, and genetic factors. Glycosylation, therefore, is a promising target of therapeutic interventions for presently incurable forms of advanced cancer....
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