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Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues

16 Oct 2023

Abstract excerpt

Harnessing the differences between cancer and non-cancer tissues presents new opportunities for selective targeting by anti-cancer drugs. CD13, a heavily glycosylated protein, is one example with significant unmet clinical potential in cancer drug discovery. Despite its high expression and activity in cancers, CD13 is also expressed in many normal tissues. Here, we report differential tissue glycosylation of CD13...

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PMID: 37942010
DOI: 10.1016/j.isci.2023.108219

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