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Structural and Functional Impact of Posttranslational Modification of Glypican-3 on Liver Carcinogenesis

7 Apr 2023

Abstract excerpt

Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in hepatocellular carcinoma (HCC). GPC3 undergoes extensive posttranslational modification (PTM) including cleavage and glycosylation. This review focuses on the structure and function of GPC3 in liver cancer, highlighting the PTM of the tertiary and quaternary structures of GPC3 as a potential oncogenic regulatory mechanism. We...

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PMID: 37027004
DOI: 10.1158/0008-5472.can-22-3895

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