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Reversal of diabetes following transplantation of an insulin-secreting human liver cell line: Melligen cells

1 Jan 2015

Abstract excerpt

As an alternative to the transplantation of islets, a human liver cell line has been genetically engineered to reverse type 1 diabetes (TID). The initial liver cell line (Huh7ins) commenced secretion of insulin in response to a glucose concentration of 2.5 mmol/l. After transfection of the Huh7ins cells with human islet glucokinase, the resultant Melligen cells secreted insulin in response to glucose within the...

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PMID: 26029722
DOI: 10.1038/mtm.2015.11

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