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Article

Islet-Like Structures Generated In Vitro from Adult Human Liver Stem Cells Revert Hyperglycemia in Diabetic SCID Mice.

Stem cell reviews and reports - 1 Feb 2019

Navarro-Tableros Victor, Gai Chiara, Gomez Yonathan, Giunti Sara, Pasquino Chiara, Deregibus Maria Chiara, Tapparo Marta, Pitino Adriana, Tetta Ciro, Brizzi Maria Felice, Ricordi Camillo, Camussi Giovanni

Abstract excerpt

A potential therapeutic strategy for diabetes is the transplantation of induced-insulin secreting cells. Based on the common embryonic origin of liver and pancreas, we studied the potential of adult human liver stem-like cells (HLSC) to generate in vitro insulin-producing 3D spheroid structures (HLSC-ILS). HLSC-ILS were generated by a one-step protocol based on charge dependent aggregation of HLSC induced by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30191384
DOI: 10.1007/s12015-018-9845-6
PMCID: PMC6510809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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