Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy.

Diabetologia - 1 Jan 2016

van der Torren Cornelis R, Zaldumbide Arnaud, Roelen Dave L, Duinkerken Gaby, Brand-Schaaf Simone H, Peakman Mark, Czernichow Paul, Ravassard Philippe, Scharfmann Raphael, Roep Bart O

Abstract excerpt

AIMS/HYPOTHESIS: Genetically engineered human beta cell lines provide a novel source of human beta cells to study metabolism, pharmacology and beta cell replacement therapy. Since the immune system is essentially involved in beta cell destruction in type 1 diabetes and after beta cell transplantation, we investigated the interaction of human beta cell lineswith the immune system to resolve their potential for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity
Share to Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement System Proteins

Share to Hyperglycemia

Share to Immune System

Share to Insulin-Secreting Cells

Share to T-Lymphocytes, Cytotoxic

Share to Th1 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 26489735
DOI: 10.1007/s00125-015-3779-1
PMCID: PMC4670455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy.PMID 26489735Read ↗

Characterisation of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cellsSemantic proximity Read ↗

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem CellsSemantic proximity Read ↗

EndoC-βH5 cells are storable and ready-to-use human pancreatic beta cells with physiological insulin secretionSemantic proximity Read ↗

Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetesSemantic proximity Read ↗

Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitroSemantic proximity Read ↗

Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection.Semantic proximity Read ↗

Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8+ T cellsSemantic proximity Read ↗

Reversal of diabetes following transplantation of an insulin-secreting human liver cell line: Melligen cellsSemantic proximity Read ↗

Cellular models for beta‐cell function and diabetes gene therapySemantic proximity Read ↗

Sensitivity profile of the human EndoC-βH1 beta cell line to proinflammatory cytokinesSemantic proximity Read ↗

Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines.Semantic proximity Read ↗

The supply chain of human pancreatic β cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.