Article
The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans Using In Vivo 123I-CLINDE SPECT Imaging: A Test-Retest Study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Jun 2017
Feng Ling, Jensen Per, Thomsen Gerda, Dyssegaard Agnete, Svarer Claus, Knudsen Lars V, Møller Kirsten, Thomsen Carsten, Mikkelsen Jens D, Guilloteau Denis, Knudsen Gitte M, Pinborg Lars H
Abstract excerpt
123I-CLINDE is a radiotracer developed for SPECT and targets the 18-kDa translocator protein (TSPO). TSPO is upregulated in glial cells and used as a measure of neuroinflammation in a variety of central nervous system diseases. The aim of this study was to examine the test-retest variability of 123I-CLINDE binding in healthy subjects. Methods: SPECT scans were acquired over 90 min in 16 healthy controls (9 women,...
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