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Article

Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.

Journal of neurovirology - 1 Jun 2014

Coughlin Jennifer M, Wang Yuchuan, Ma Shuangchao, Yue Chen, Kim Pearl K, Adams Ashley V, Roosa Heidi V, Gage Kenneth L, Stathis Marigo, Rais Rana, Rojas Camilo, McGlothan Jennifer L, Watkins Crystal C, Sacktor Ned, Guilarte Tomas R, Zhou Yun, Sawa Akira, Slusher Barbara S, Caffo Brian, Kassiou Michael, Endres Christopher J, Pomper Martin G

Abstract excerpt

Imaging the brain distribution of translocator protein (TSPO), a putative biomarker for glial cell activation and neuroinflammation, may inform management of individuals infected with HIV by uncovering regional abnormalities related to neurocognitive deficits and enable non-invasive therapeutic monitoring. Using the second-generation TSPO-targeted radiotracer, [(11)C]DPA-713, we conducted a positron emission...

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Identifiers

PMID: 24567030
DOI: 10.1007/s13365-014-0239-5
PMCID: PMC4078660

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.PMID 24567030Read ↗

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