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Article

Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease.

Human genetics - 1 Aug 2015

Zhang Xu, Zhang Wei, Saraf Santosh L, Nouraie Mehdi, Han Jin, Gowhari Michel, Hassan Johara, Miasnikova Galina, Sergueeva Adelina, Nekhai Sergei, Kittles Rick, Machado Roberto F, Garcia Joe G N, Gladwin Mark T, Steinberg Martin H, Sebastiani Paola, McClain Donald A, Gordeuk Victor R

Abstract excerpt

Environmental variations have strong influences in the etiology of type 2 diabetes mellitus. In this study, we investigated the genetic basis of diabetes in patients with sickle cell disease (SCD), a Mendelian disorder accompanied by distinct physiological conditions of hypoxia and hyperactive erythropoiesis. Compared to the general African American population, the prevalence of diabetes as assessed in two SCD...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26025476
DOI: 10.1007/s00439-015-1572-3
PMCID: PMC4607040

Genes

SCD
APOB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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